- Associations Between Estimated Desaturase Activity and Insulin Resistance in Korean Boys
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Young Sim Choi, Han Byul Jang, Ju Yeon Park, Hye-Ja Lee, Jae-Heon Kang, Kyung-Hee Park, Jong Ho Lee, Sang Ick Park, Jihyun Song
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Osong Public Health Res Perspect. 2014;5(5):251-257. Published online October 31, 2014
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DOI: https://doi.org/10.1016/j.phrp.2014.08.008
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 Abstract
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- Objectives
Obesity in childhood increases the risk of obesity in adulthood, and is predictive of the development of metabolic disorders. The fatty acid compositions of various tissues, including blood, are associated with obesity and obesity-associated disorders. Thus, tracking plasma phospholipid (PL) features and metabolic parameters in young individuals may strengthen the utility of fatty acid composition as an early biomarker of future metabolic disorders.
Methods
Anthropometric and blood biochemical data were obtained from 131 Korean males aged 10.5 ± 0.4 years, and followed up at 2 years. We analyzed the plasma PL fatty acids according to obesity. Obese children were defined as those with a body mass index (BMI) greater than the 85th percentile for age and gender, based on Korean child growth standards.
Results
Activities of lipid desaturases, stearyl-CoAD (SCD-16,16:1n-7/16:0), delta-6D (D6D, 20:3n-6/18:2n-6), and delta-5D (D5D, 20:4n-6/20:3n-6), were estimated. Obese individuals had significantly higher proportions of palmitoleic acid (16:1n-7) and dihomo-gamma linolenic acid (DGLA, 20:3n-6) at both baseline and follow-up than did lean individuals. The activities of SCD-16 and D6D were higher in obese than lean boys. The baseline SCD-16 activity level was positively associated with the baseline waist circumference (WC) and the metabolic risk score. The baseline D6D level was positively associated with WC and also with the homeostasis model of assessment of insulin resistance (HOMA-IR), a surrogate marker of insulin resistance (IR), and metabolic risk score at both baseline and follow-up.
Conclusion
In young Korean males, higher D6D activity predicts the future development of IR and associated metabolic disorders including dyslipidemia.
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Citations
Citations to this article as recorded by  - Palmitoleic and Dihomo-γ-Linolenic Acids Are Positively Associated With Abdominal Obesity and Increased Metabolic Risk in Children
Man-Chin Hua, Hui-Min Su, Ming-Wei Lai, Tsung-Chieh Yao, Ming-Han Tsai, Sui-Ling Liao, Shen-Hao Lai, Jing-Long Huang
Frontiers in Pediatrics.2021;[Epub] CrossRef - Is Palmitoleic Acid a Plausible Nonpharmacological Strategy to Prevent or Control Chronic Metabolic and Inflammatory Disorders?
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Molecular Nutrition & Food Research.2018;[Epub] CrossRef - Associations Among Fatty Acids, Desaturase and Elongase, and Insulin Resistance in Children
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Venkatesh Gopalan, Navin Michael, Seigo Ishino, Swee Shean Lee, Adonsia Yating Yang, K. N. Bhanu Prakash, Jadegoud Yaligar, Suresh Anand Sadananthan, Manami Kaneko, Zhihong Zhou, Yoshinori Satomi, Megumi Hirayama, Hidenori Kamiguchi, Bin Zhu, Takashi Hori
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